HDI Polyisocyanates: Toxicity and Airborne Concentration Guidelines
Chemical Structures
Chemical Structure
Molecular Weight and Vapor Pressure
Typical 2-Component PU Paint Formulations
Volatility
Inhalation Exposure Potential
During Paint Application
Why Study Polyisocyanate Toxicity and Exposure?
Purpose
Selection Criteria for Toxicity Studies
Subchronic Toxicity Study Design
Subchronic Toxicity Study Design (continued)
Subchronic Toxicity Study Endpoints
Subchronic Inhalation Toxicity Study with HDI Monomer
Subchronic Inhalation Toxicity Study with Biuret-type HDI Polyisocyanate
Subchronic Inhalation Toxicity Study with Isocyanurate Polyisocyanate
Discussion/Summary of Toxicity Studies
History of Polyiso Tox. And Exp. Studies by Producers
UK Isocyanate Control Limits
Total Mass vs. TRIG
Total Mass vs. TRIG 8 Hour Concentration Guidelines
Total Mass vs. TRIG STEL/C Conc. Guidelines
Why Not Accept Silk & Hardy Hypothesis?
Why Not Accept Silk & Hardy Hypothesis
Monomer vs. Polyiso Toxicity Comparison
“No Difference” Hypothesis Wrong
Conclusion
Email: jmyers@aiha.org
Home Page: http://www.aiha.org
Best experienced with Click here to start.
Download presentation source
