NIOSH has issued a request for information on toluene diisocyanate (TDI), one of the most commonly used diisocyanates. The agency intends to evaluate the scientific data on TDI to develop and establish an updated recommended exposure limit (REL) for the chemical. The current NIOSH REL for 2,4-TDI is the lowest feasible concentration with no ceiling due to the potential carcinogenicity of TDI. NIOSH requests information about the following:
published and unpublished reports and findings from in vitro and in vivo toxicity studies with TDI
information on possible health effects observed in workers exposed to TDI
description of work tasks and scenarios with a potential for exposure to TDI
information on control measures that are being used in workplaces with potential exposure to TDI
surveillance findings, including protocol, methods, and results
According to NIOSH, occupational exposure to TDI occurs during the production and use of diisocyanates, including the mixing and foaming processes in the polyurethane foam industry as well as during the spray adhesive application in the automobile and furniture industries. Exposure to TDI may irritate the eyes, skin, and the gastrointestinal and respiratory tracts.
For more information, view the Federal Register notice. The comment period ends on Aug. 8, 2013. Comments may be submitted on Regulations.gov.