HDI Polyisocyanates: Toxicity and Airborne Concentration Guidelines

9/12/00


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Table of Contents

HDI Polyisocyanates: Toxicity and Airborne Concentration Guidelines

Chemical Structures

Chemical Structure

Molecular Weight and Vapor Pressure

Typical 2-Component PU Paint Formulations

Volatility

Inhalation Exposure Potential

During Paint Application

Why Study Polyisocyanate Toxicity and Exposure?

Purpose

Selection Criteria for Toxicity Studies

Subchronic Toxicity Study Design

Subchronic Toxicity Study Design (continued)

Subchronic Toxicity Study Endpoints

Subchronic Inhalation Toxicity Study with HDI Monomer

Subchronic Inhalation Toxicity Study with Biuret-type HDI Polyisocyanate

Subchronic Inhalation Toxicity Study with Isocyanurate Polyisocyanate

Discussion/Summary of Toxicity Studies

History of Polyiso Tox. And Exp. Studies by Producers

UK Isocyanate Control Limits

UK Isocyanate Control Limits

Total Mass vs. TRIG

Total Mass vs. TRIG

Total Mass vs. TRIG 8 Hour Concentration Guidelines

Total Mass vs. TRIG STEL/C Conc. Guidelines

Why Not Accept Silk & Hardy Hypothesis?

Why Not Accept Silk & Hardy Hypothesis

Monomer vs. Polyiso Toxicity Comparison

“No Difference” Hypothesis Wrong

Conclusion

Author: Bayer

Email: jmyers@aiha.org

Home Page: http://www.aiha.org

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