Federal Agency Publishes New Toxicological Profiles for Three Chemicals

New final toxicological profiles for the chemicals hexachlorobutadiene, 1,1,2-trichloroethane, and endrin are now available from the Agency for Toxic Substances and Disease Registry. Hexachlorobutadiene is primarily used to make rubber compounds, and 1,1,2-trichloroethane is used in chemical production and as a solvent. Endrin, a pesticide used to control insects, rodents, and birds, has not been produced or used in the U.S. in 30 years. According to ATSDR, most people do not need to take special steps to avoid hexachlorobutadiene and endrin in their daily lives. The agency urges workers who use or produce 1,1,2-trichloroethane to use appropriate personal protective equipment. Similarly, consumers using solvents or adhesive containing the chemical should avoid breathing in fumes and skin contact with these products.

EPA has classified both hexachlorobutadiene and 1,1,2-trichloroethane as possible human carcinogens. The agency’s website states that endrin is “not classifiable as to human carcinogenicity.” The NIOSH Pocket Guide to Chemical Hazards provides information about exposure limits for hexachlorobutadiene, 1,1,2-trichloroethane, and endrin.

ATSDR’s toxicological profiles characterize the toxicological and adverse health effects information for hazardous substances. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicological properties. Information on the potential for human exposure; chemical and physical properties; regulations and guidelines; and production, import, use, and disposal can also be found in ATSDR’s toxicological profiles. A full list of toxic substances with published profiles is available on the agency’s website.