Toxicological Challenges to the Derivation and Application of Occupational Exposure Limits


Risk Assessment and Management, Toxicology

Arranger: M. Deveau, University of Ottawa, Ottawa, ON, Canada. Moderator: K. Still, Portland State University, Portland, OR. Monitors: J. Fallon-Carine, GE Oil & Gas, Carson City, NV; B. Bidstrup, H2 Compliance Inc., Hanover, NH.

Occupational exposure limits (OELs) are important tools that allow industrial hygienists to interpret measured levels of chemicals in the workplace. Although the high-level approaches used in the derivation of OELs tend to be consistent among compounds, certain toxicological properties of chemicals can create challenges in the derivation of the values. Industrial hygienists should also provide special consideration to these toxicological challenges when using the OELs to interpret exposure measurements. This session will introduce the state of the science for several of the toxicological challenges associated with OELs and present case studies of chemicals for which these challenges have emerged.

Overview of the Toxicological Basis of OELs
A. Maier, University of Cincinnati, Cincinnati, OH.

Complexities in Deriving and Interpreting OELs for Chemical Irritants
A. Maier, University of Cincinnati, Cincinnati, OH.

Setting OELs for Chemical Allergens: Understanding the Challenges
S. Dotson, NIOSH, Cincinnati, OH.

Challenges in the Derivation and Application of OELs for Developmental and Reproductive Toxicants
T. Lewandowski, Gradient, Seattle, WA.

Aligning OELs and Exposures
M. Jayjock, Jayjock Associates, LLC, Langhorne, PA.

A Framework for the Selection of an Appropriate OEL
M. Deveau, University of Ottawa, Ottawa, ON, Canada.

Interpretation of Risks at Exposures Above and Below OELs
L. Beyer, Gradient, Cambridge, MA.

Presented at AIHce 2015 in Salt Lake, Utah.​