NIOSH Proposes Draft Method for Detection, Quantitation of 3-Bromopropionic Acid

Published April 16, 2014

NIOSH requests public comment on a new method proposed for inclusion in the fifth edition of the NIOSH Manual of Analytical Methods (NMAM) titled “Method 8324: 3-Bromopropionic acid in urine; A metabolite of 1-bromopropane.” The method was developed for the detection and quantitation of 3-bromopropionic acid, a human metabolite of 1-bromopropane and proposed biomarker of exposure, in human urine. The draft method is available for download as a PDF from

According to the agency, 1-Bromopropane is an industrial solvent that is often used as a substitute for a number of chlorofluorocarbon solvents that were withdrawn from use because of their possible damaging effects to the ozone layer.

Comments are due by June 10. For more information, see the Federal Register notice or visit the docket page on

NMAM is a collection of methods for sampling and analysis of contaminants in workplace air, and in the blood and urine of workers who are occupationally exposed. The occupational health and safety community can use more than 300 methods in NMAM to measure worker exposures. The manual also includes chapters on quality assurance, sampling, portable instrumentation, and more. NMAM is available on NIOSH’s website.