NIOSH Requests Review of Draft IDLH Values for Bromine Trifluoride, Other Chemicals

Published June 13, 2018

NIOSH requests technical review of new draft immediately dangerous to life or health values for the chemicals bromine trifluoride, chlorine trifluoride, and ethylene dibromide. Each of the draft “IDLH value profiles” is intended to summarize the health hazards of acute exposures to high airborne concentrations of a chemical and discuss the rationale for the chemical’s proposed IDLH value.

NIOSH set the IDLH value for bromine trifluoride at 10 ppm (56 mg/m3). Because data were inadequate to directly derive an IDLH value for bromine trifluoride, the agency used data from studies with chlorine trifluoride—a chemical with similar structure, reaction mechanisms, and potency—to develop the value for BrF3. The IDLH value for chlorine trifluoride is set at 10 ppm (38 mg/m3), and is based on a median lethal concentration of 178 ppm in mice exposed for 60 minutes. The IDLH value for ethylene dibromide, 36 ppm (277 mg/m3), is based on a 45-minute median lethal concentration value of 800 ppm in rats.

NIOSH asks reviewers to consider whether the IDLH value profiles clearly outline the health hazards associated with acute exposures to each chemical and whether the rationale and logic behind the IDLH value derivation is clearly explained. The agency also requests feedback on whether the documents are organized appropriately, the conclusions are supported by the data, and the included tables are clear and appropriate.

The comment period for these documents closes on Aug. 7, 2018. See the Federal Register notice for information about submitting comments.

For more information on IDLH values, visit the NIOSH website​.​​​​​