Two New Interaction Profiles Available from ATSDR

Two new final interaction profiles are available from the Agency for Toxic Substances and Disease Registry. ATSDR’s interaction profiles are intended to characterize information on toxicologic and adverse health effects for mixtures of hazardous substances. One of the new profiles focuses on chemicals that the agency says present the likelihood of co-exposure in the home: carbon monoxide, formaldehyde, methylene chloride, nitrogen dioxide, and tetrachloroethylene. The mixture of chemicals examined in the other interaction profile—chloroform, 1,1-dichloroethene, trichloroethylene, and vinyl chloride—frequently occur in water around hazardous waste sites, according to ATSDR. In both publications, the agency recommends that exposure assessments of mixtures use “component-based approaches that assume additive joint toxic action.” The interaction profile on mixtures of chloroform, 1,1-dichloroethene, trichloroethylene, and vinyl chloride additionally mentions oral exposure as a concern.

The interaction profiles for carbon monoxide, formaldehyde, methylene chloride, nitrogen dioxide, and tetrachloroethylene and for chloroform, 1,1-dichloroethene, trichloroethylene, and vinyl chloride can be found on the ATSDR website. Additional information and other interaction profiles for toxic substances are also available.